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The disease is majorly diagnosed in women though carcinoma of the male breast has also been described with prevalence not well elucidated.

The disease is majorly diagnosed in women though carcinoma of the male breast has also been described with prevalence not well elucidated.

Please write a rebuttal in agreement to:Mrs. Conway is one of my favorite aunts from our paternal side. Four years ago she undertook genetic testing after presenting to her primary care physician with complaints of a breast lump. She was found to have a BRCA-1 gene mutation, which makes her high risk of developing breast cancer and a relative risk for developing ovarian carcinoma. At only 33 years of age, my vibrant aunt who works as a community social worker has had a generally unremarkable health history. She has had countable hospital visits in her adult age during most of which she was treated as an outpatient for minor ailments. Family history is significant of our grandmother who died from cardiorespiratory arrest secondary to pulmonary thromboembolism. She was on treatment for stage-4 breast cancer that was diagnosed at age 45.Having a BRCA-1 gene mutation carries up to 85% risk of developing carcinoma of the breast and other cancers as well including ovarian carcinoma (Rebbeck, 2015). The disease is majorly diagnosed in women though carcinoma of the male breast has also been described with prevalence not well elucidated. The disease often presents as a breast lump that may have been picked during a routine breast exam or incidentally. The lump is often painless and danger signs include rapid growth, irregular borders with a suggestive history such as that of breast cancer diagnosed at an early age in a first-degree relative (Broek, 2015). Other known risk factors include nulliparity, early menarche and delayed menopause, estrogen treatment, smoking among others.As alluded to earlier, having a BRCA-1 gene mutation also predisposes her to ovarian carcinoma. This condition can be easily averted if my aunt decides to have a bilateral oophorectomy (Broek, 2015). This is an example of a modifiable risk factor that exists for her. More studies are being done to understand breast cancer and particularly the link of genetics to its development. However, as it stands, the risk is well defined for BRCA-1 AND BRCA-2 mutations. (Rebbeck, 2015).


 

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